Publications Timeline

Explore our research contributions and scientific discoveries over the years

27
Total Publications
2025
Latest Year

Highlighted Publications

9.2
Impact
2025

EGFR-mutated non-small cell lung cancer

X Ma, X Li

BMJ. 2025 Jun 5;389:r1154. doi: 10.1136/bmj.r1154.

Editorial Corresponding
PubMed DOI
15.3
Impact
2022

Solving the puzzle of what makes immunotherapies work

X Ma, TA Chan.

Trends in Cancer. 2022 Nov;8(11):890-900. doi: 10.1016/j.trecan.2022.06.011.

Review
DOI
41.3
Impact
2022

Functional Landscapes of POLE and POLD1 Mutations in Checkpoint Blockade-Dependent Anti-Tumor Immunity

X Ma, N Riaz, RM Samstein, M Lee, V Makarov, C Valero, D Chowell, F Kuo, D Hoen, CWR Fitzgerald, H Jiang, J Alektiar, TJ Alban, I Juric, PB Parthasarathy, Y Zhao, EY Sabio, R Verma, RM Srivastava, L Vuong, W Yang, X Zhang, J Wang, LK Chu, SL Wang, DW Kelly, X Pei, J Chen, R Yaeger, D Zamarin, A Zehir, M Gönen, LGT Morris and TA Chan.

Nature Genetics. 2022 Jul;54(7):996-1012. doi: 10.1038/s41588-022-01108-w.

DOI
23.8
Impact
2020

Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy

RM Samstein*, C Krishna*, X Ma*, X Pei, KW Lee, V Makarov, F Kuo, J Chung, RM Srivastava, TA Purohit, DR Hoen, R Mandal, J Setton, W Wu, R Shah, B Qeriqi, Q Chang, S Kendall, L Braunstein, B Weigelt, PBC Albornoz, LGT Morris, DL Mandelker, JS Reis-Filho, E Stanchina, SN Powell, TA Chan, N Riaz. (* co-first author)

Nature Cancer. 16 Nov 2020, 1(12):1188-1203. DOI: 10.1038/s43018-020-00139-8.

DOI
7.8
Impact
2017

CAMK2γ Promotes Colitis-Associated Colorectal Carcinogenesis via Enhancing STAT3 Activation

X Ma*, Z Meng*, L Jin, Z Xiao, X Wang, WM Tsark, L Ding, Y Gu, J Zhang, BW Kim, M He, X Gan, JE Shively, H Yu, R Xu, W Huang. (* co-first author)

Oncogene. 2017 Jul 13;36(28):4060-4071.

DOI
7.8
Impact
2017

CAMK2γ Antagonizes mTORC1 Activation during Hepatocarcinogenesis

Z Meng*, X Ma*, J Du, X Wang, M He, Y Gu, J Zhang, W Han, Z Fang, X Gan, CV Ness, X Fu, D Schones, R Xu, W Huang. (* co-first author)

Oncogene. 2017 Apr 27;36(17):2446-2456.

DOI

Other Recent Publications

2025

Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer

B Rousseau, M Patel, O Artz, G Vlachos, S Patel, O Hayatt, G Argilés, MB Foote, L Luo, R Shah, S Mehta, K Rangavajhula, CM Stewart, D Gerber, R Bhattacharya, D Stephens, D Mieles, V Randrian, S Abdelfattah, L Zhang, N Membreno-Berganza, MF Lamendola-Essel, F Piastra-Facon, J Vidal, P Johannet, S Lu, JR White, SB Maron, A Barlas, CM Weipert, E Rosiek, T Zhang, B He, S Monette, R Qu, D Fidele, S Bowker, A Kahn, PP Vitiello, G Germano, A Bardelli, R Mandal, X Ma, TA Chan, S Lu, A Cercek, O Abdel-Wahab, E de Stanchina, NH Segal & LA Diaz Jr.

Cancer Cell. 2025 Jul 14;43(7):1313–1327.e10.

DOI
2024

Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab

TJ Alban, N Riaz, P Parthasarathy, V Makarov, S Kendall, S Yoo, R Shah, N Weinhold, R Srivastava, X Ma, C Krisha, JY Mok, WJE Esch, E Garon, W Akerley, B Creelan, N Aanur, D Chowell, WJ Geese, NA Rizvi & TA Chan.

Nature Medicine. https://doi.org/10.1038/s41591-024-03240-y

DOI
2022

A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear Cell Renal Cell Carcinoma

PM Rappold, L Vuong, J Leibold, NH Chakiryan, M Curry, F Kuo, E Sabio, H Jiang, BG Nixon, M Liu, AE Berglund, AW Silagy, A Mascareno, M Golkaram, M Marker, A Reising, A Savchenko, JM Millholland, Y Chen, P Russo, J Coleman, E Reznik, BJ Manley, I Ostrovnaya, V Makarov, RG DiNatale, KA Blum, X Ma, D Chowell, MO Li, DB Solit, SW Lowe, TA Chan, RJ Motzer, MH Voss, AA Hakimi.

Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-21-0925

DOI
2022

A complex leads to autophagic degradation of CDK2 in cancer cells

J Zhang, Y Gan, H Li, J Yin, X He, L Lin, S Xu, Z Fang, B Kim, L Gao, L Ding, E Zhang, X Ma, J Li, L Li, Y Xu, D Horne, R Xu, H Yu, Y Gu, W Huang.

Nature Commnunications. https://doi.org/10.1038/s41467-022-30264-0

DOI
2022

The Hippo Pathway Mediates Semaphorin Signaling

Z Meng, F Li, C Fang, B Yeoman, Y Qiu, Y Wang, X Cai, KC Lin, D Yang, M Luo, V Fu, X Ma, Y Diao, FG Giancotti, B Ren, AJ Engler, KL Guan.

Science Advances. https://doi.org/10.1126/sciadv.abl9806

DOI
2022

Phenotypic and Molecular States of IDH1 Mutation- Induced CD24-Positive Glioma Stem-Like Cells

S Haddock, TJ Alban, Ş Turcan, H Husic, E Rosiek, X Ma, Y Wang, T Bale, A Desrichard, V Makarov, S Monette, W Wu, R Gardner, K Manova, A Boire, TA Chan.

Neoplasia. https://10.1016/j.neo.2022.100790

DOI
2021

Improved prediction of immune checkpoint blockade efficacy across multiple cancer types

D Chowell, SK Yoo, C Valero, A Pastore, C Krishna, M Lee, D Hoen, H Shi, DW Kelly, N Patel, V Makarov, X Ma, L Vuong, EY Sabio, K Weiss, F Kuo, TL Lenz, RM Samstein, N Riaz, VBPS Adusumilli, G Plitas, AA Hakimi, O Abdel-Wahab, AN Shoushtari, MA Postow, RJ Motzer, M Ladanyi, A Zehir, MF Berger, M Gönen, LGT Morris, N Weinhold, TA Chan.

Nature Biotechnology. DOI: 10.1038/s41587-021-01070-8

DOI
2021

Qa-1b Modulates Resistance to Anti–PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing

X Zhang, E Sabio, C Krishna, X Ma, J Wang, H Jiang, JJ Havel, TA Chan

Molecular Cancer Research. DOI: https://doi.org/10.1158/1541-7786.MCR-20-0652

DOI
2021

Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice

L Ding, E Zhang, Q Yang, L Jin, KM Sousa, B Dong, Y Wang, J Tu, X Ma, J Tian, H Zhang, Z Fang, A Guan, Y Zhang, Z Wang, DD Moore, L Yang, W Huang.

Proceedings of the National Academy of Sciences (PNAS). https://doi.org/10.1073/pnas.2019388118.

DOI
2020

Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas

Y Wang, AT Wild, S Turcan, WH Wu, C Sigel, DS Klimstra, X Ma, Y Gong, EC Holland, JT Huse, TA Chan.

Science Advances, 2020 Apr 22;6(17):eaaz3221. doi: 10.1126/sciadv.aaz3221. eCollection 2020 Apr.

DOI
2019

Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response

R Mandal, RM Samstein, KW Lee, JJ Havel, H Wang, C Krishna, EY Sabio, V Makarov, F Kuo, P Blecua, AT Ramaswamy, JN Durham, B Bartlett, X Ma, RM Srivastava, S Middha, A Zehir, JF Hechtman, LGT Morris, N Weinhold, N Riaz, DT Le, LA Diaz Jr, TA Chan.

Science, 2019 May 3;364(6439):485-491 DOI: 10.1126/science.aau0447.

DOI

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